Karel Výborný

Karel Výborný (born 1973) is a Czech neuroscientist and biomedical researcher affiliated with the Institute of Experimental Medicine (IEM CAS) and the Second Faculty of Medicine of Charles University in Prague.

Career

Výborný works at the Department of Biomaterials and Tissue Engineering at the Institute of Experimental Medicine in Prague, Czech Republic, and has also been affiliated with the Second Faculty of Medicine at Charles University. His scientific contributions primarily concern the development and characterization of extracellular matrix scaffolds derived from human and animal tissues, aiming to promote regeneration of the central nervous system after injury.

He has co-authored several influential papers in the field of tissue engineering and regenerative neuroscience, collaborating with researchers including Šárka Kubinová, Eva Syková, and Pavla Jendelová.

Research

Výborný's research focuses on neural tissue engineering, extracellular matrix (ECM) hydrogels, and biomaterials for spinal cord and neural repair. His research demonstrated that crosslinking human umbilical cord–derived extracellular matrix hydrogels with genipin significantly improved their mechanical stability, resistance to enzymatic degradation, and in vivo biocompatibility, making them more effective materials for neural tissue repair. In experimental in vivo models, the genipin-crosslinked hydrogels showed prolonged retention and integration in neural tissue without eliciting immune or inflammatory responses. He is also involved in software engineering and computational neuroscience, focusing on modeling neural processes and the application of artificial intelligence in biomedical research. In addition, Výborný works on computational neuroscience and software engineering tools supporting neuroinformatics, data analysis, and simulation of neural systems.

Selected publications

  • Tukmachev D. et al. Injectable Extracellular Matrix Hydrogels as Scaffolds for Spinal Cord Injury Repair. Tissue Engineering Part A 22 (2016) 306–317. DOI 1.
  • Koci Z. et al. Extracellular Matrix Hydrogel Derived from Human Umbilical Cord as a Scaffold for Neural Tissue Repair and Its Comparison with Extracellular Matrix from Porcine Tissues. Tissue Engineering Part C: Methods (2017) 333–345. DOI 2.
  • Vyborny K. et al. Genipin and EDC Crosslinking of Extracellular Matrix Hydrogel Derived from Human Umbilical Cord for Neural Tissue Repair. Scientific Reports 9 (2019) 10674. DOI 3.
  • Mikšík I. et al. Analysis of Chondroitin/Dermatan Sulphate Disaccharides Using High-Performance Liquid Chromatography. Separations 7 (2020) 49. DOI 4.
  • Výborný K., Kubinová S. Extracellular Matrix Scaffolds in Tissue Engineering. In Nanomaterials in Biomedical Research. Prague: CZECH-IN, 2017. ISBN 978-80-906655-5-2.