Sebastian Springer

Sebastian Springer (born February 24, 1966) is a German biochemist. He is a professor of biochemistry and cell biology at Jacobs University Bremen, whose research work focuses on MHC class I molecules.
Education and Career
Springer received his Diploma studies in Biochemistry from the University of Tübingen in Germany in 1992. Later on he joined Friedrich-Miescher-Laboratory of the Max Planck Society, Tübingen, Germany and obtained his Diploma thesis with Stefan Jentsch. In 1996, he obtained his D.Phil from the University of Oxford, UK. In 2001, he joined Randy Schekman at University of California, Berkeley, USA. There he became a senior postdoctoral research associate and worked on vesicular transport in yeast cells. In 2001 he joined Jacobs University Bremen as an assistant professor of Biochemistry and Cell Biology to later became an independent research group leader working on MHC class I trafficking.
Academic Awards
*1988-1992: Stipend of the Studienstiftung des Deutschen Volkes (German NationalScholarship Foundaton).
*1992-1995: Wellcome Trust Prize Studentship.
*2002: Ernst-A.-C.-Lange-Preis of the Society of the Friends of the Universities in Bremen.
*2004, 2006, 2012: Teaching awards, School of School of Engineering and Science, Jacobs University Bremen.
*2008 and 2013: Professor of the Year, School of Engineering and Science, Jacobs University Bremen
*2013: MOOC Production Fellowship, Stifterverband der Deutschen Wissenschaft.
Selected Publications
His work on MHC class I molecules and vesicular transport has been highly cited and discussed by other researchers. He wrote, coauthored and published a number of research papers, some of which include:
* Nucleation of COPII vesicular coat complex by endoplasmic reticulum to Golgi vesicle SNAREs.
* Controlled intracellular release of peptides from microcapsules enhances antigen presentation on MHC class I molecules.
* Calreticulin-dependent recycling in the early secretory pathway mediates optimal peptide loading of MHC class I molecules.
* Tapasin dependence of major histocompatibility complex class I molecules correlates with their conformational flexibility.
* Dipeptides promote folding and peptide binding of MHC class I molecules.
Other Academic Achievements
As a distinguished professor at Jacobs University Bremen,</ref> Springer designed a number of study programs such as Biochemistry and Cell Biology (BSc) Program and Molecular Life Science (MSc) Program. He also delivers regular talks at prominent universities including Cambridge University and the University of Oxford. Springer participated in launching an open free online course entitled “DNA - From Structure to Therapy”, which discusses the strategies that are followed in order to use DNA for the development of diagnostics and therapeutics.

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