Pseudomonas aeruginosa Mannose Sensitive Hemagglutinin

Pseudomonas aeruginosa Mannose Sensitive Hemagglutinin (PA-MSHA), trade name Wantepuan, marketed by Beijing Wanter Biopharmaceutical Co, LTD, approved by China Food and Drug Administration, is a drug used for prevention of infection, particularly Pseudomonas infection, and treatment of cancer. PA-MSHA is an artificial recombinant strain of P. aeruginosa, and inactivated with formaldehyde. When injected into the body, it will activate the immune response which in turn clears any infected cells and/or pathogens and attacks the cancerous cells in the body.
Mechanism of action
After randomly recombining the genetic materials of a wild type strain of P. aeruginosa with E. coli, the strain over-expresses Type I fimbriae, a type of fimbria that specifically binds to terminal mannose residues of polysaccharides. Wild type P. aeruginosa does not have type I fimbira genes in the genome but only type IV pilus, which is much lower in number on the bacteria surface.

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