KEGG Cancer

KEGG Cancer is an integrated resource of various types of cancer information stored in KEGG PATHWAY, KEGG BRITE, KEGG DISEASE, KEGG DRUG, KEGG COMPOUND, and KEGG GLYCAN databases.
Featutes of KEGG Cancer Database
*Overview of Cancer maps
Signaling network of pathways in cancer
Transcriptional network describing transcriptional misregulation in cancers
microRNAs in cancer
Proteoglycans in cancer
Chemical carcinogenesis of Cancer
Viral carcinogenesis
*KEGG pathway maps (14 specific cancer types)
*Cancer-associated genes
*KEGG DISEASE entries (55 different cancers)
*Environmental factors
*KEGG COMPOUND entries in BRITE classifications (Carcinogens, Endocrine disrupting compounds, Pesticides, etc.)
Drugs for cancer
*KEGG DRUG entries in BRITE classifications (Antineoplastics and other drug classifications)
*KEGG DRUG structure maps (Chronology: Antineoplastics)
KEGG Mapping of Somatic Mutation Frequency
COSMIC data for colorectal cancer mapped on "Pathways in cancer"
The KEGG pathway maps for 14 cancers contain oncogenes and tumor suppressor genes with genetic alterations summarized in the gray box and also marked in red in the pathway. This is based on literature data. In contrast, the Sanger Institute's COSMIC (Catalogue Of Somatic Mutations In Cancer) database contains actual observations of genetic alterations in cancer genomes. Here the COSMIC data for 27 cancers (see detail of selecting COSMIC site and histology) are mapped against KEGG pathways using one of the tools of KEGG Mapper. The result can be viewed from the follwing link:
*KEGG Atlas 3D viewer
To analyze own data one can use KEGG mapper tool.
Color Pathway 3D
KEGG Mapping of Cancer Stages
The KEGG pathway maps for 14 cancers are drawn in a stage-dependent manner; how different signaling pathways and cancer-related genes are involved at different stages of oncogenesis. This is summarized in the following BRITE hierarchy file:
Cancer stages together with links to the snapshots of involved pathways in the signaling overview map and the individual maps.

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