The Rothstein lab is located at the Columbia Universtiy Medical Center in NY city, and is lead by professor Rodney Rothstein of Columbia University. The lab began its research in 1977 and has mapped out many of the important pathways involved in DNA repair as well as making much progress in understanding genetic recombination in eukaryotes. The lab primarily works with yeast, although many of the genes are conserved with humans. The lab is part of the Genetics and Development department at the Columbia University Julius & Armand Hammer Health Sciences Center. The Rad52 and Sml1 proteins, as well as the Top3/Sgs1 protein complex, are the major proteins researched. The lab has a complete gene disruption library for yeast of all non-essential genes, making across the board genome screening and gene study a useful tool.
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