Current Protocols in Human Genetics is a resource for all types of research and clinical laboratory approaches pertaining to human genetics. It covers disease-gene mapping, large-scale molecular cloning methods, linkage and association studies, and analysis of sequence variants and larger-scale genomic structure. Many of the protocols here are equally applicable to other eukaryotic organisms, including the mouse. Topics Covered Biochemical Genetics • Identifying Candidate Genes in Genomic DNA • Cancer Genetics • Clinical Cytogenetics • Clinical Molecular Genetics • Conventional and Molecular Genetics • Forensic Genetics • Genetic Association Studies • Genetic Linkage Studies • Genome Structure Analysis • Genotyping • Model Systems for the Analysis of Human Disease • Detecting Mutations and Variants