Angiotensinogen core promoter element

Angiotensinogen core promoter element 1 (AGCE1) is an example of a core promoter element that may occur in a DNA sequence for only one gene (the human angiotensinogen gene angiotensin).
Core promoter
The 'core promoter' is the minimal portion of the promoter required to properly initiate gene transcription. It contains a binding site for RNA polymerase (RNA polymerase I, RNA polymerase II, or RNA polymerase III). A vast network of regulatory factors that contribute to the initiation of transcription by RNA polymerase ultimately target any specific gene’s core promoter.
AGCE1 can occur upstream from -25 to -1 base pairs (bp)s of the transcription start site.
Transcriptional activity
Within the variation allowed by the consensus sequence, it is likely that the transcriptional activities of an E-box-like motif of two juxtaposed AGCE1 elements have the following ratios: CTC/CTC and ATC/ATC homozygotes or the CTC/ATC heterozygotes are 2.5 times higher than that of the ATT/ATT homozygote and that the CTC/ATT and ATC/ATT heterozygotes are 1.75 times higher than that of the ATT/ATT homozygote.

Main Menu

See Also

Main Menu