|
EIF4E basal element
|
|
EIF4E basal element, also eIF4E, (4EBE) is a basal promoter element for the eukaryotic translation initiation factor 4E. Interactions between 4EBE and upstream activator sites are position, distance, and sequence dependent. Eukaryotic translation initiation factor 4E 'Eukaryotic translation initiation factor 4E', also known as 'eIF4E', is a protein which in humans is encoded by the eIF4E gene. Consensus sequence The consensus sequence is 3'-TTCCCCCCCATT-5' in the direction of transcription.<ref name=Lynch/> DNA-binding protein Specific DNA-binding proteins, including YY1, TFII-I, USF, and E2F, bind initiator elements (Inr)s.<ref name=Lynch/> Although 4EBE appears similar to an Inr, it is not transactivated by YY1, does not cross-compete with known initiator sequences, is not supershifted by antibodies to any known initiator-binding proteins, and does not bind SP1.<ref name=Lynch/> See Also
|
| < Prev | Next > |
|---|
Main Menu
| Home |
| Articles |
| Search |
| Submit Article |
| Contact Us |
| Donate to Wikibin |
