List of Great Lakes Airlines destinations

Over its history Great Lakes Airlines was known to have flown to 163 airports in 161 cities, Chicago having been served through three airports. Most of its destinations were served as United Express, a code-share affiliate for United Airlines, through the 1990s until 2002. A second code-share operation with Midway Airlines known as Midway Connection was flown in the mid-1990s. From 2002 all flights were flown under the carrier's own brand. Great Lakes Airlines was also the largest Essential Air Service (EAS) provider in the United States for many years but only served two of its cities through the EAS program prior to ceasing operations. At the time of its shutdown, Great Lakes Airlines flew to the following domestic scheduled destinations:

  • Arizona
    • Prescott (Ernest A. Love Field)
    • Page Municipal Airport
    • Phoenix Sky Harbor International Airport Hub
  • California
    • Los Angeles International Airport Hub
  • Colorado
    • Denver International Airport Hub
    • Telluride Regional Airport
  • Wyoming
    • Cheyenne Regional Airport

Terminated destinations before closure

  • Arizona
    • Kingman Airport
    • Show Low Regional Airport
    • Sierra Vista Municipal Airport
    • Tucson International Airport Former hub
  • California
    • LA/Ontario International Airport Former hub
    • Merced Regional Airport
    • Orange County (John Wayne Airport)
    • Visalia Municipal Airport
  • Colorado
    • Alamosa (San Luis Valley Regional Airport)
    • Cortez Municipal Airport
    • Grand Junction Regional Airport
    • Gunnison-Crested Butte Regional Airport
    • Lamar Municipal Airport
    • Steamboat Springs/Hayden-Yampa Valley Airport
  • Indiana
    • Bloomington (Monroe County Airport)
    • Lafayette (Purdue University Airport)
    • Muncie (Delaware County Airport)
    • Terre Haute International Airport (Hulman Field)
  • Illinois
    • Carbondale (Southern Illinois Airport)
    • Chicago (O'Hare International Airport) Former hub
    • Chicago (Merrill C. Meigs Field)
    • Chicago (Midway International Airport)
    • Danville (Vermilion Regional Airport)
    • Decatur Airport
    • Galesburg Municipal Airport
    • Marion (Williamson County Regional Airport)
    • Mattoon (Coles County Memorial Airport)
    • Mount Vernon Airport
    • Quincy Regional Airport
    • Sterling/Rock Falls (Whiteside County Airport)
    • Springfield (Abraham Lincoln Capital Airport)
  • Iowa
    • Burlington (Southeast Iowa Regional Airport)
    • Clinton Municipal Airport
    • Des Moines International Airport
    • Dubuque Regional Airport
    • Fort Dodge Regional Airport
    • Mason City Municipal Airport
    • Ottumwa Regional Airport
    • Sioux City (Sioux Gateway Airport)
    • Spencer Municipal Airport
    • Waterloo Regional Airport
  • Kansas
    • Dodge City Regional Airport
    • Garden City Regional Airport
    • Great Bend Municipal Airport
    • Goodland Municipal Airport
    • Hays Regional Airport
    • Liberal Mid-America Regional Airport
    • Manhattan Regional Airport
    • Salina Regional Airport
  • Michigan
    • Alpena County Regional Airport
    • Detroit (Detroit Metropolitan Wayne County Airport) Former Hub
    • Escanaba (Delta County Airport)
    • Hancock/Houghton (Houghton County Memorial Airport)
    • Iron Mountain (Ford Airport)
    • Ironwood (Gogebic–Iron County Airport)
    • Lansing (Capitol Region International Airport)
    • Manistee County Blacker Airport
    • Marquette (Sawyer International Airport)
    • Menominee/Marinette (Twin County Airport)
    • Muskegon County Airport
    • Pellston Regional Airport
    • Sault Ste. Marie (Chippewa County International Airport)
    • Traverse City (Cherry Capital Airport)
  • Minnesota
    • Bemidji Regional Airport
    • Duluth International Airport
    • Fairmont Municipal Airport
    • Fergus Falls Municipal Airport
    • Mankato Regional Airport
    • Minneapolis–Saint Paul International Airport Former hub
    • Thief River Falls Regional Airport
    • Worthington Municipal Airport
  • Missouri
    • Cape Girardeau Regional Airport
    • Fort Leonard Wood (Waynesville Regional Airport at Forney Field)
    • Joplin Regional Airport
    • Kansas City International Airport Former hub
    • Lambert–St. Louis International Airport Former hub
  • Montana
    • Billings Logan International Airport Former hub
    • Glasgow Airport (U.S.)
    • Glendive, Montana (Dawson Community Airport)
    • Havre City–County Airport
    • Lewistown Municipal Airport
    • Miles City Airport
    • Sidney–Richland Municipal Airport
    • Wolf Point, Montana (L. M. Clayton Airport)
  • Nebraska
    • Alliance Municipal Airport
    • Chadron Municipal Airport
    • Grand Island (Central Nebraska Regional Airport)
    • Kearney Regional Airport
    • McCook Regional Airport
    • Norfolk Regional Airport
    • North Platte Regional Airport
    • Omaha (Eppley Airfield)
    • Scottsbluff (Western Nebraska Regional Airport)
  • New Mexico
    • Albuquerque International Sunport Former hub
    • Clovis Municipal Airport
    • Farmington (Four Corners Regional Airport)
    • Gallup Municipal Airport
    • Santa Fe Municipal Airport
    • Silver City (Grant County Airport)
  • Nevada
    • Ely Airport
    • Las Vegas (McCarran International Airport) Former hub
  • North Dakota
    • Bismarck Municipal Airport
    • Devils Lake Regional Airport
    • Dickinson Theodore Roosevelt Regional Airport
    • Fargo (Hector International Airport)
    • Grand Forks International Airport
    • Jamestown Regional Airport
    • Minot International Airport
    • Williston (Sloulin Field International Airport)
  • Oklahoma
    • Enid Woodring Regional Airport
    • Ponca City Regional Airport
  • South Dakota
    • Aberdeen Regional Airport
    • Brookings Regional Airport
    • Huron Regional Airport
    • Mitchell Municipal Airport
    • Pierre Regional Airport
    • Rapid City Regional Airport
    • Sioux Falls Regional Airport
    • Watertown Regional Airport
    • Yankton (Chan Gurney Municipal Airport)
  • Texas
    • Amarillo (Rick Husband Amarillo International Airport)
  • Utah
    • Moab Canyonlands Field
    • Vernal Regional Airport
  • Wisconsin
    • Manitowoc County Airport
    • Milwaukee (General Mitchell International Airport) Former hub
    • Oshkosh (Wittman Regional Airport)
    • Sturgeon Bay (Door County Cherryland Airport)
    • Rhinelander–Oneida County Airport
  • Wyoming
    • Casper–Natrona County International Airport
    • Cody (Yellowstone Regional Airport)
    • Gillette–Campbell County Airport
    • Laramie Regional Airport
    • Rock Springs–Sweetwater County Airport
    • Sheridan County Airport
    • Riverton Regional Airport
    • Worland Municipal Airport
  • Mexico
    • Ciudad Obregon International Airport
    • Guaymas (General José María Yáñez International Airport)
    • Hermosillo International Airport
    • Puerto Penasco International Airport
  • Routes served as Midway Connection 1995-1997:
  • Raleigh–Durham International Airport Former Hub
    • Ashville, NC
    • Baltimore, MD
    • Charleston, SC
    • Columbia, SC
    • Columbus, OH
    • Greenville, SC/Spartanburg, SC
    • Harrisburg, PA
    • Hilton Head, SC
    • Jacksonville, FL
    • Myrtle Beach, SC
    • Norfolk, VA
    • Richmond, VA
    • Savannah, GA
    • Wilmington, NC