José Antonio López Guerrero

José Antonio López Guerrero (JAL) (*Madrid, 1962) is an Associate Professor of Microbiology at the Department of Molecular Biology at the Universidad Autónoma de Madrid (UAM), a researcher and director of the Scientific Culture Department of the Molecular Biology Center Severo Ochoa (CBMSO ) and a collaborator in several scientific cultural programs on radio, television and in the press.

Education

After finishing his secondary studies in Hanover (Germany), and at the Cervantes institute (Madrid), Prof. López Guerrero studied Biology (BSc Biochemistry) at the Autonomous University of Madrid (1980–1985). His Ph.D. research was conducted at CBMSO and concerned the scientific field of immunovirology; 1989 -special award 1990-. Subsequently, he moved as a postdoctoral researcher to the Center for Biological Research (CIB-CSIC, 1990–1993) and The German Center of Cancer Research (DKFZ, 1993–1996). When Prof. López Guerrero returned to the UAM, he was given several positions as Assistant Professor and Head of science communication programs. In 2001 he became an Associate Professor and since 2003 he has directed, as Group leader, a small research laboratory on Neurovirology. Prof. López Guerrero coordinated, between 2006–2009, the Scientific Culture Unit of the UAM and since 2006 the Department of the same name at the CBMSO.

Research

  • PhD Study (1986-1989. CBMSO. Madrid): Study of the susceptibility of immune cells to virus infection.
  • First Postdoctoral Work (1990-1993. CIB. Madrid): Study of Rheumatoid Arthritis in a Murine Model.
  • Second Postdoctoral Study (1993-1996. DKFZ): Study of U937 promonocytic cell clones selected for their resistance to parvovirus H-1 infection.
  • Since 1996 (CBMSO UAM-CSIC): HSV-1 infection and neurodegeneration.

Books

  • “¿Qué es un Transgénico? (y las madres que lo parieron)”. 2001 y 2008. Editorial Sirius.
  • “Células Madre: la madre de todas las células”. 2003. Ed. Hélice.
  • “La Tesis de Rebeca. Apuntes de una joven investigadora”. 2004 y 2009. Ed. Hélice.
  • “Sé lo que ocurrió... los cursos pasados”. 2006. Ed. Hélice.
  • “Células madre y terapia regenerativa”. RANF. 2009.

Some significant references

  • López-Guerrero,J.A., Carrasco, L., Martínez-Abarca, F., Fresno, M. y Alonso, M.A. (1989). "Restriction of poliovirus RNA translation in a human monocytic cell line". Eur.J.Biochem., 186: 577-582.
  • López-Guerrero,J.A., López-Bote, J.P., Ortíz, M.A., Páez, E. y Bernabeu, C. (1993). "Recombinant vaccinia virus for human heat shock protein ameliorates adjuvant arthritis". Infect.Immun., 61:4225-31.
  • López-Guerrero,J.A., Ortíz, M.A., Páez, E., Bernabeu, C. y López-Bote, J.P. (1994). "Therapeutic effect of the recombinat vaccinia virus expressing the 60-kilodanton heat shock protein on adjuvant arthritis". Arth.Rheum., 37: 1462-67.
  • López-Guerrero,J.A., Rayet, B., Tuynder, M., Rommelaere, J. and Dinsart, C. "Constitutive activation of U937 promonocytic cell clones selected for their resistance to parvovirus H-1 infection". (1997). Blood, 89: 1642-1653.
  • Hass, R. and López-Guerrero, J.A. "Aggressive tumor growth of human TUR leukemia cells is associated with high levels of c-Myc expression and down regulation of p20-Max". (1997). Int.J.Cancer, 72:1-4.
  • López-Guerrero, J.A. and Carrasco, L. " Effect of nitric oxide on poliovirus infection of two human cell lines" (1998). J.Virol., 72:2538-40.
  • Rayet, B., López-Guerrero, J.A., Rommelaere, J. and Dinsart, C.: "Induccion of programmed cell death by parvovirus H-1 in U-937 cells: Connection with the TNFa signalling patway" (1998). J.Virol., 72:8893-8903.
  • López-Guerrero, J.A., Alonso, M., Martin-Belmonte, F. and Carrasco, L. "Poliovirus induces apoptosis in the human promonocytic cell line U937" (2000). Virology., 272:250-256.
  • López-Guerrero, J.A., Martin-Belmonte, F., Carrasco, L. and Alonso, M.A.: "The N-myristoylated nine amino acid sequence from the amino terminus of poliovirus capsid VP4 protein is sufficient for targeting to perinuclear structures containing detergent-insoluble membranes" (2000). Biochemistry., 39:1083-1090.
  • Alonso, M., Dimitrijevic, A., Recuero, M., Serrano, E., Valdivieso F. and López-Guerrero, J.A. "Interaction of alpha-2-Macroglobulin and HSV-1 during infection of neuronal cells" (2001). J.NeuroVirol., 7: 556-63.
  • Bello-Morales, R., Fedetz, M., Alcina, A., Tabarés, E. and López-Guerrero, J.A. “High susceptibility of a human oligodendroglial cell line to herpes simplex type 1 infection”. (2005). J.NeuroVirol. 11:190-198.
  • Bello-Morales, R., de Marco, M.C., Aranda, J.F., Matesanz, F., Alcina, A. and López-Guerrero, J.A. “Characterization of the MAL2 positive compartment in oligodendrocytes”. (2009). Exp.Cell.Res. 315:3453-65.

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