ICD-10 Chapter IV: Endocrine, nutritional and metabolic diseases

(E00-E07) Thyroid gland / Thyroid hormone

() Congenital iodine-deficiency syndrome

() Iodine-deficiency-related thyroid disorders and allied conditions
- () Iodine-deficiency-related diffuse (endemic) goitre
- () Iodine-deficiency-related multinodular (endemic) goitre
- () Iodine-deficiency-related (endemic) goitre, unspecified
- () Other iodine-deficiency-related thyroid disorders and allied condition

() Subclinical iodine-deficiency hypothyroidism
() Other hypothyroidism
- () Congenital hypothyroidism with diffuse goitre
- () Congenital hypothyroidism without goitre
- () Hypothyroidism due to medicaments and other exogenous substances
- () Postinfectious hypothyroidism
- () Atrophy of thyroid (acquired)
- () Myxoedema coma
() Other nontoxic goitre

() Thyrotoxicosis (hyperthyroidism)
- () Thyrotoxicosis with diffuse goitre
  - Graves' disease
- () Thyrotoxicosis with toxic single thyroid nodule
- () Thyrotoxicosis with toxic multinodular goitre
- () Thyrotoxicosis from ectopic thyroid tissue
- () Thyrotoxicosis factitia
- () Thyroid crisis or storm
- () Other thyrotoxicosis
- () Thyrotoxicosis, unspecified

() Thyroiditis
- () Acute thyroiditis
- () Subacute thyroiditis
  - De Quervain's thyroiditis
- () Chronic thyroiditis with transient thyrotoxicosis
- () Autoimmune thyroiditis
  - Hashimoto's thyroiditis
- () [...]-induced thyroiditis
- () Other chronic thyroiditis
  - Riedel's thyroiditis
- () Thyroiditis, unspecified

() Other disorders of thyroid
- () Hypersecretion of calcitonin
- () Dyshormogenetic goitre
- () Other specified disorders of thyroid
  - Sick-euthyroid syndrome
- () Disorder of thyroid, unspecified

(E10-E16) Pancreas / Insulin, glucagon

(E10-E14) Diabetes mellitus

Note: the following conditions are subtypes of each code from E10-14:
- (E1x.0) Diabetic coma
- (E1x.1) Diabetic ketoacidosis
- (E1x.2) Diabetic nephropathy
- (E1x.3) Diabetic retinopathy
- (E1x.4) Diabetic neuropathy
- (E1x.5) Diabetic angiopathy
- (E1x.6) Diabetic arthropathy
() Insulin-dependent diabetes mellitus
() Non-insulin-dependent diabetes mellitus
() Malnutrition-related diabetes mellitus
() Other specified diabetes mellitus
() Unspecified diabetes mellitus

(E15-E16) Other disorders of glucose regulation and pancreatic internal secretion

() Nondiabetic hypoglycaemic coma
- - [...]-induced insulin coma in nondiabetic
  - Hyperinsulinism with hypoglycaemic coma
  - Hypoglycaemic coma NOS

() Other disorders of pancreatic internal secretion
- () [...]-induced hypoglycaemia without coma
- () Other hypoglycaemia
  - Functional nonhyperinsulinaemic hypoglycaemia
  - Hyperinsulinism: NOS
  - Hyperinsulinism: functional
  - Hyperplasia of pancreatic islet beta cells NOS
  - Posthypoglycaemic coma encephalopathy
- () Hypoglycaemia, unspecified
- () Increased secretion of glucagon
- () Abnormal secretion of gastrin
  - Hypergastrinaemia
  - Zollinger-Ellison syndrome
- () Other specified disorders of pancreatic internal secretion
- () Disorder of pancreatic internal secretion, unspecified

(E20-E21) Parathyroid gland / PTH

() Hypoparathyroidism
- () Idiopathic hypoparathyroidism
- () Pseudohypoparathyroidism

() Hyperparathyroidism and other disorders of parathyroid gland
- () Primary hyperparathyroidism
- () Secondary hyperparathyroidism, not elsewhere classified

(E22-E23) Pituitary gland / ADH, oxytocin, GH, ACTH, TSH, LH, FSH, prolactin

() Hyperfunction of pituitary gland
- () Acromegaly and pituitary gigantism
- () Hyperprolactinaemia
- () Syndrome of inappropriate secretion of antidiuretic hormone
  - Central precocious puberty

() Hypofunction and other disorders of pituitary gland
- () Hypopituitarism
  - Fertile eunuch syndrome
  - Hypogonadotropic hypogonadism
  - Idiopathic growth hormone deficiency
  - Isolated deficiency of gonadotropin
  - Isolated deficiency of growth hormone
  - Isolated deficiency of pituitary hormone
  - Kallmann's syndrome
  - Lorain-Levi short stature
  - Necrosis of pituitary gland (postpartum)
  - Panhypopituitarism
  - Pituitary cachexia
  - Pituitary insufficiency NOS
  - Pituitary short stature
  - Sheehan's syndrome
  - Simmonds' disease
- () [...]-induced hypopituitarism
- () Diabetes insipidus
- () Hypothalamic dysfunction, not elsewhere classified
- () Other disorders of pituitary gland
  - Abscess of pituitary
  - Adiposogenital dystrophy
- () Disorder of pituitary gland, unspecified

(E24-E27) Adrenal gland / Aldosterone, cortisol, epinephrine, norepinephrine

() Cushing's syndrome
- () Pituitary-dependent Cushing's disease
- () Nelson's syndrome
- () Ectopic ACTH syndrome
- () Alcohol-induced pseudo-Cushing's syndrome
- () Other Cushing's syndrome
- () Cushing's syndrome, unspecified

() Adrenogenital disorders
- () Congenital adrenogenital disorders associated with enzyme deficiency
  - Congenital adrenal hyperplasia
    - Congenital adrenal hyperplasia due to 21-hydroxylase deficiency

() Hyperaldosteronism
- () Primary hyperaldosteronism
  - Conn's syndrome
  - Primary aldosteronism due to adrenal hyperplasia (bilateral)
- () Secondary hyperaldosteronism
- () Other hyperaldosteronism
  - Bartter's syndrome
- () Hyperaldosteronism, unspecified

() Other disorders of adrenal gland
- () Other adrenocortical overactivity
- () Primary adrenocortical insufficiency
  - Addison's disease
- () Addisonian crisis
- () [...]-induced adrenocortical insufficiency
- () Other and unspecified adrenocortical insufficiency
  - Hypoaldosteronism
  - Adrenocortical insufficiency NOS
- () Adrenomedullary hyperfunction

(E28-E30) Gonads / Estrogen, androgens, testosterone, etc.

() Ovarian dysfunction
- () Estrogen excess
- () Androgen excess
- () Polycystic ovarian syndrome
- () Primary ovarian failure
  - Premature menopause NOS

() Testicular dysfunction
- () Testicular hyperfunction
- () Testicular hypofunction
  - 5-Alpha-reductase deficiency (with male pseudohermaphroditism)
  - Testicular hypogonadism NOS

() Disorders of puberty, not elsewhere classified
- () Delayed puberty
- () Precocious puberty
- () Other disorders of puberty
  - Premature thelarche

(E31-E35) Other

() Polyglandular dysfunction
- () Autoimmune polyglandular failure
  - Schmidt's syndrome
- () Polyglandular hyperfunction

() Diseases of thymus
- () Persistent hyperplasia of thymus
- () Abscess of thymus

() Other endocrine disorders
- () Carcinoid syndrome
- () Other hypersecretion of intestinal hormones
- () Ectopic hormone secretion, not elsewhere classified
- () Short stature, not elsewhere classified
  - NOS
  - constitutional
  - Laron-type
  - psychosocial
- () Constitutional tall stature
  - Constitutional gigantism
- () Androgen resistance syndrome
  - Reifenstein's syndrome
- () Other specified endocrine disorders
  - Progeria

() Disorders of endocrine glands in diseases classified elsewhere
- () Disorders of thyroid gland in diseases classified elsewhere
- () Disorders of adrenal glands in diseases classified elsewhere
- () Disorders of other endocrine glands in diseases classified elsewhere

E40-68 - Nutritional diseases

(E40-E46) Malnutrition

() Kwashiorkor
() Nutritional marasmus
() Marasmic kwashiorkor
() Unspecified severe protein-energy malnutrition
() Protein-energy malnutrition of moderate and mild degree
() [...] development following protein-energy malnutrition
() Unspecified protein-energy malnutrition

(E50-E64) Other nutritional deficiencies

() VITAMIN A deficiency
- () Vitamin A deficiency with conjunctival xerosis
- () Vitamin A deficiency with Bitot's spot and conjunctival xerosis
- () Vitamin A deficiency with corneal xerosis
- () Vitamin A deficiency with corneal ulceration and xerosis
- () Vitamin A deficiency with keratomalacia
- () Vitamin A deficiency with night blindness
- () Vitamin A deficiency with xerophthalmic scars of cornea
- () Other ocular manifestations of vitamin A deficiency
  - Xerophthalmia NOS
() Thiamine deficiency
- () Beriberi
- () Wernicke's encephalopathy
() Niacin deficiency (pellagra)
() Deficiency of other B group vitamins
- () Riboflavin deficiency
  - Ariboflavinosis
- () Pyridoxine deficiency
- () Deficiency of other specified B group vitamins
() Ascorbic acid deficiency
- Scurvy
() Vitamin D deficiency
- () Rickets, active
() Other vitamin deficiencies
- () Deficiency of vitamin E
- () Deficiency of vitamin K
() Dietary calcium deficiency
() Dietary selenium deficiency
() Dietary zinc deficiency
() Deficiency of other nutrient elements
- () Iron deficiency
- () Magnesium deficiency
- () Manganese deficiency
- () Chromium deficiency
- () Molybdenum deficiency
- () Vanadium deficiency
() Other nutritional deficiencies
- () Essential fatty acid (EFA) deficiency
() Sequelae of malnutrition and other nutritional deficiencies

(E65-E68) Obesity and other hyperalimentation

() Localized adiposity
- Fat pad

() Obesity
- () Obesity due to excess calories
- () [...]-induced obesity
- () Extreme obesity with alveolar hypoventilation
  - Pickwickian syndrome
- () Other obesity
  - Morbid obesity
- () Obesity, unspecified

() Other hyperalimentation
- () Hypervitaminosis A
- () Hypercarotenaemia
- () Megavitamin-B 6 syndrome
- () Hypervitaminosis D

() Sequelae of hyperalimentation

E70-E90 - Metabolic diseases

(E70-E79) Metabolic disorders of proteins, fats, and carbohydrates

(E70-E72) Amino-acids

() Disorders of aromatic amino-acid metabolism
- () Classical phenylketonuria
- () Other hyperphenylalaninaemias
- () Disorders of tyrosine metabolism
  - Alkaptonuria (ILDS E70.210)
  - Ochronosis (ILDS E70.230)
  - Tyrosinaemia
- () Albinism
  - Chediak-Higashi syndrome
  - Cross syndrome
  - Hermansky-Pudlak syndrome
- () Other disorders of aromatic amino-acid metabolism
  - Disorders of histidine metabolism
  - Disorders of tryptophan metabolism
- () Disorder of aromatic amino-acid metabolism, unspecified

() Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
- () Maple-syrup-urine disease
- () Other disorders of branched-chain amino-acid metabolism
  - Propionic acidemia
  - Methylmalonic acidemia
  - Isovaleric acidemia
- () Disorder of branched-chain amino-acid metabolism, unspecified
- () Disorders of fatty-acid metabolism
  - Adrenoleukodystrophy (Addison-Schilder)
  - Muscle carnitine palmityltransferase deficiency

() Other disorders of amino-acid metabolism
- () Disorders of amino-acid transport
  - Cystinuria
  - Cystinosis
  - Hartnup disease
  - Lowe's syndrome
- () Disorders of sulfur-bearing amino-acid metabolism
  - Cystathioninuria
  - Homocystinuria
  - Methioninaemia
  - Sulfite oxidase deficiency
- () Disorders of urea cycle metabolism
  - Argininaemia
  - Argininosuccinic aciduria
  - Citrullinaemia
  - Hyperammonaemia
- () Disorders of lysine and hydroxylysine metabolism
  - Glutaric aciduria
  - Hydroxylysinaemia
  - Hyperlysinaemia
- () Disorders of ornithine metabolism
  - Ornithinaemia (types I, II)
- () Disorders of glycine metabolism
  - Hyperhydroxyprolinaemia
  - Hyperprolinaemia (types I, II)
  - Non-ketotic hyperglycinaemia
  - Sarcosinaemia

(E73-E74) Carbohydrates

() Lactose intolerance

() Other disorders of carbohydrate metabolism
- () Glycogen storage disease
  - Glycogen storage disease type I (von Gierke's disease)
  - Glycogen storage disease type II (Pompe's disease)
  - Glycogen storage disease type III
  - Glycogen storage disease type IV
  - Glycogen storage disease type V (McArdle's disease)
- () Disorders of fructose metabolism
  - Essential fructosuria
  - Fructose-1,6-diphosphatase deficiency
  - Hereditary fructose intolerance
- () Disorders of galactose metabolism
  - Galactosaemia
  - Galactokinase deficiency
- () Other disorders of intestinal carbohydrate absorption
  - Glucose-galactose malabsorption
  - Sucrase deficiency
- () Disorders of pyruvate metabolism and gluconeogenesis
  - Deficiency of phosphoenolpyruvate carboxykinase
  - Deficiency of pyruvate carboxylase
  - Deficiency of pyruvate dehydrogenase
- () Other specified disorders of carbohydrate metabolism
  - Essential pentosuria
  - Oxalosis
  - Oxaluria
  - Renal glycosuria
- () Disorder of carbohydrate metabolism, unspecified

(E75) Lipids

() Disorders of sphingolipid metabolism and other lipid storage disorders
- () GM 2 gangliosidosis
  - Sandhoff disease
  - Tay-Sachs disease
- () Other gangliosidosis
  - GM 1
  - GM 3
  - Mucolipidosis IV
- () Other sphingolipidosis
  - Gaucher's disease (ILDS E75.220)
  - Niemann-Pick disease (ILDS E75.230)
  - Farber's disease (ILDS E75.240)
  - Fabry's disease (ILDS E75.250)
- () Sphingolipidosis, unspecified
- () Neuronal ceroid lipofuscinosis
  - Batten disease (Type 3)
  - Bielschowsky-Jansky disease (Type 2)
  - Kufs disease (Type 4)
  - Spielmeyer-Vogt disease (Type 3)
- () Other lipid storage disorders
  - Cerebrotendinous cholesterosis (van Bogaert-Scherer-Epstein)
  - Wolman's disease
- () Lipid storage disorder, unspecified

(E76-E78) Combinations

() Disorders of glycosaminoglycan metabolism
- () Mucopolysaccharidosis, type I
  - Hurler syndrome
- () Mucopolysaccharidosis, type II
  - Hunter syndrome
- () Other mucopolysaccharidoses
  - Sanfilippo syndrome
  - Morquio syndrome

() Disorders of glycoprotein metabolism
- () Defects in post-translational modification of lysosomal enzymes
  - Mucolipidosis II (I-cell disease)
  - Mucolipidosis III (pseudo-Hurler polydystrophy)
- () Defects in glycoprotein degradation
  - Aspartylglucosaminuria
  - Fucosidosis
  - Mannosidosis
  - Sialidosis (mucolipidosis I)

() Disorders of lipoprotein metabolism and other lipidaemias
- () Pure hypercholesterolaemia
  - Familial hypercholesterolaemia
  - Fredrickson's hyperlipoproteinaemia, type IIa
  - Hyperbetalipoproteinaemia
  - Hyperlipidaemia, group A
  - Low-density-lipoprotein-type (LDL) hyperlipoproteinaemia
- () Pure hyperglyceridaemia
  - Endogenous hyperglyceridaemia
  - Fredrickson's hyperlipoproteinaemia, type IV
  - Hyperlipidaemia, group B
  - Hyperprebetalipoproteinaemia
  - Very-low-density-lipoprotein-type (VLDL) hyperlipoproteinaemia
- () Mixed hyperlipidaemia
  - Broad- or floating-betalipoproteinaemia
  - Fredrickson's hyperlipoproteinaemia, type IIb or III
  - Hyperbetalipoproteinaemia with prebetalipoproteinaemia
  - Hypercholesterolaemia with endogenous hyperglyceridaemia
  - Hyperlipidaemia, group C
  - Tubero-eruptive xanthoma
  - Xanthoma tuberosum
- () Hyperchylomicronaemia
  - Fredrickson's hyperlipoproteinaemia, type I or V
  - Hyperlipidaemia, group D
  - Mixed hyperglyceridaemia
- () Other hyperlipidaemia
  - Familial combined hyperlipidaemia
- () Hyperlipidaemia, unspecified
- () Lipoprotein deficiency
  - Abetalipoproteinaemia
  - High-density lipoprotein deficiency
  - Hypoalphalipoproteinaemia
  - Hypobetalipoproteinaemia (familial)
  - Lecithin cholesterol acyltransferase deficiency
  - Tangier disease

(E79-E90) Other metabolic disorders

() Disorders of purine and pyrimidine metabolism
- () Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
- () Lesch-Nyhan syndrome
- () Other disorders of purine and pyrimidine metabolism
  - Hereditary xanthinuria

() Disorders of porphyrin and bilirubin metabolism
- () Hereditary erythropoietic porphyria
  - Erythropoietic protoporphyria (ILDS E80.010)
  - Erythropoietic porphyria, congenital (ILDS E80.020)
  - Gunther's disease (ILDS (ILDS E80.020)
  - Erythropoietic porphyria (ILDS (ILDS E80.030)
  - Erythropoietic coproporphyria (ILDS E80.040)
- () Porphyria cutanea tarda
  - Sporadic porphyria cutanea tarda (ILDS E80.110)
  - Familial porphyria cutanea tarda (ILDS E80.120)
- () Other porphyria
  - Acute intermittent porphyria (ILDS E80.210)
  - Hereditary coproporphyria (ILDS E80.222)
  - Variegate porphyria (ILDS E80.230)
  - Chester porphyria (ILDS E80.232)
  - Porphyria, hepatic (ILDS E80.240)
  - Pseudoporphyria (ILDS E80.250)
  - Toxic porphyria (ILDS E80.260)
  - Hepatoerythropoietic porphyria (ILDS E80.282)
  - Porphyria, NOS (ILDS E80.290)
- () Defects of catalase and peroxidase
  - Acatalasia (Takahara)
- () Gilbert's syndrome
- () Crigler-Najjar syndrome
- () Other disorders of bilirubin metabolism
  - Dubin-Johnson syndrome
  - Rotor's syndrome
- () Disorder of bilirubin metabolism, unspecified

() Disorders of mineral metabolism
- () Disorders of copper metabolism
  - Wilson's disease
  - Menkes disease
- () Disorders of iron metabolism
  - Hemochromatosis
- () Disorders of zinc metabolism
  - Acrodermatitis enteropathica
- () Disorders of phosphorus metabolism
  - Acid phosphatase deficiency
  - Familial hypophosphataemia
  - Hypophosphatasia
  - Vitamin-D-resistant osteomalacia
  - Vitamin-D-resistant rickets
- () Disorders of magnesium metabolism
  - Hypermagnesemia
  - Hypomagnesemia
- () Disorders of calcium metabolism
  - Familial hypocalciuric hypercalcaemia
  - Idiopathic hypercalciuria

() Cystic fibrosis

() Amyloidosis
- () Non-neuropathic heredofamilial amyloidosis
  - Familial Mediterranean fever
  - Hereditary amyloid nephropathy
- () Neuropathic heredofamilial amyloidosis
  - Amyloid polyneuropathy (Portuguese)
- () Heredofamilial amyloidosis, unspecified
- () Secondary systemic amyloidosis
  - Haemodialysis-associated amyloidosis
- () Organ-limited amyloidosis
  - Localized amyloidosis
- () Other amyloidosis
- () Amyloidosis, unspecified

() Volume depletion
- Dehydration
- Hypovolaemia

() Other disorders of fluid, electrolyte and acid-base balance
- () Hyperosmolality and hypernatraemia
- () Hypo-osmolality and hyponatraemia
- () Acidosis
  - Respiratory acidosis
  - Metabolic acidosis
  - Lactic acidosis
- () Alkalosis
- () Mixed disorder of acid-base balance
- () Hyperkalaemia
- () Hypokalaemia
- () Fluid overload
- () Other disorders of electrolyte and fluid balance, not elsewhere classified
  - Electrolyte imbalance NOS
  - Hyperchloraemia
  - Hypochloraemia

() Other metabolic disorders
- () Disorders of plasma-protein metabolism, not elsewhere classified
  - Alpha-1-antitrypsin deficiency
- () Lipodystrophy, not elsewhere classified
- () Lipomatosis, not elsewhere classified

() Postprocedural endocrine and metabolic disorders, not elsewhere classified
- () Postprocedural hypothyroidism
- () Postprocedural hypoinsulinaemia
- () Postprocedural hypoparathyroidism
- () Postprocedural hypopituitarism
- () Postprocedural ovarian failure
- () Postprocedural testicular hypofunction
- () Postprocedural adrenocortical(-medullary) hypofunction

() Nutritional and metabolic disorders in diseases classified elsewhere

Main Menu

ICD-10 Chapter IV: Endocrine, nutritional and metabolic diseases

(E00-E07) Thyroid gland / Thyroid hormone

(E10-E16) Pancreas / Insulin, glucagon

(E10-E14) Diabetes mellitus

(E15-E16) Other disorders of glucose regulation and pancreatic internal secretion

(E20-E21) Parathyroid gland / PTH

(E22-E23) Pituitary gland / ADH, oxytocin, GH, ACTH, TSH, LH, FSH, prolactin

(E24-E27) Adrenal gland / Aldosterone, cortisol, epinephrine, norepinephrine

(E28-E30) Gonads / Estrogen, androgens, testosterone, etc.

(E31-E35) Other

E40-68 - Nutritional diseases

(E40-E46) Malnutrition

(E50-E64) Other nutritional deficiencies

(E65-E68) Obesity and other hyperalimentation

E70-E90 - Metabolic diseases

(E70-E79) Metabolic disorders of proteins, fats, and carbohydrates

(E70-E72) Amino-acids

(E73-E74) Carbohydrates

(E75) Lipids

(E76-E78) Combinations

(E79-E90) Other metabolic disorders

See also

ICD-10 Chapter IV: Endocrine, nutritional and metabolic diseases

(E00-E07) Thyroid gland / Thyroid hormone

(E10-E16) Pancreas / Insulin, glucagon

(E10-E14) Diabetes mellitus

(E15-E16) Other disorders of glucose regulation and pancreatic internal secretion

(E20-E21) Parathyroid gland / PTH

(E22-E23) Pituitary gland / ADH, oxytocin, GH, ACTH, TSH, LH, FSH, prolactin

(E24-E27) Adrenal gland / Aldosterone, cortisol, epinephrine, norepinephrine

(E28-E30) Gonads / Estrogen, androgens, testosterone, etc.

(E31-E35) Other

E40-68 - Nutritional diseases

(E40-E46) Malnutrition

(E50-E64) Other nutritional deficiencies

(E65-E68) Obesity and other hyperalimentation

E70-E90 - Metabolic diseases

(E70-E79) Metabolic disorders of proteins, fats, and carbohydrates

(E70-E72) Amino-acids

(E73-E74) Carbohydrates

(E75) Lipids

(E76-E78) Combinations

(E79-E90) Other metabolic disorders

See also

See Also

ICD-10 Chapter II: Neoplasms; Chapter III: Diseases of the blood and blood-forming organs, and certain disorders involving the immune mechanism

ICD-10 Chapter I: Certain infectious and parasitic diseases

ICD-10 Chapter XXI: Factors influencing health status and contact with health services

ICD-10 Chapter XX: External causes of morbidity and mortality

ICD-10 Chapter XIX: Injury, poisoning and certain other consequences of external causes