Dean P. Jones

Dean P. Jones (born September 13, 1949) is an American scientist in biomedical and environmental research. He is Professor of Medicine and Biochemistry and Director of the Clinical Biomarkers Laboratory at Emory University School of Medicine, Atlanta, Georgia. His research career has focused on redox biology, metabolism and mechanisms of cell death. His pioneering research to map intracellular gradients of oxygen, hydrogen peroxide, ATP and pH in mammalian cells provided a foundation for later discovery of kinetic limitations in thiol/disulfide systems. He elaborated an article, “The Redox Code” together with Helmut Sies, providing central principles for an organism, defined by a genetic code, to organize bioenergetics, metabolism and macromolecular structure to utilize environmental resources and defend against environmental challenges. The redox code complements the genetic code in the molecular logic of life. His current research extends these concepts to practical approaches to understand human exposures and cumulative effects, termed the exposome, and develop understanding of exposure memory systems that impact healthy aging and chronic disease. He worked with Gary W. Miller, Ph.D., to establish HERCULES (Health and Exposome Research Center: Understanding Lifetime Exposures), the first Human Exposome Research Center in the Americas.

Selected publications

• Jones, D. P. Passion and Joy when I'm 64.
• Jones, D. P. Radical-Free Biology of Oxidative Stress.
• Jones, D. P. Redefining Oxidative Stress.
• Cai, J, Jones. D.P. Superoxide in Apoptosis. Mitochondrial Generation Triggered by Cytochrome C Loss.
• Jones, D. P. Redox potential of GSH/GSSG couple: assay and biological significance.
• Go, Y.-M., Jones, D. P. Redox compartmentalization in eukaryotic cells.
• Jones, D. P., Go, Y.-M., Anderson, C. L., Ziegler, T. R., Kinkade, J. M. Jr., Kirlin, W. G.
• Jones, D. P., Park, Y., Ziegler, T. R. Nutritional metabolomics: progress in addressing complexity in diet and health.
• Jones, D. P. Free Radic Biol Med: Measuring the Poise of Thiol/Disulfide Couples in vivo.
• Cribbs, S. K., Park, Y., Guidot, D. M., Martin, G. S., Brown, L., Lennox, J. and Jones, D. P. Metabolomics of Bronchoalveolar Lavage Differentiate Healthy HIV-1-Infected Subjects from Controls.