The Londinium Pedo is an annual treasure hunt which takes place on a Sunday afternoon in late September or early October each year within the Square Mile of the City of London (the financial centre of the United Kingdom). It is organised by the United Hospitals and University of London Motoring Club (UHULMC). Despite being organised by a motoring club, the event takes place on foot. It is a sister event to the Miglia Quadrato, which is a car-based treasure hunt which takes place every May, also organised by UHULMC.
The hunt explores the streets and maze of alleyways of an area still rich in history and hidden delights and curiosities. The city is virtually deserted away from the tourist magnets of St Paul's Cathedral and The Monument.
Format
Participation is as individuals or teams of two. The Pedo lasts for three hours, and is made up of six consecutive thirty minute stages. A team starts at one of six checkpoints at a given starting time, is handed the first clue sheet, and makes its way to the next checkpoint during the allotted thirty minutes. Penalty points are accrued if a team is late arriving at a checkpoint.
Each clue sheet details a number of inscriptions to find (any written material is fair game, including graffiti, plaques, manhole covers, graves and so on). A point is scored for each answer obtained.
A 'Mini Pedo' version, which uses a smaller number of the clues on each clue sheet is recommended for newcomers.
The all-time record score is 71/72, obtained by Salem Al-Damluji and Anna Griffiths in 2014.
The hunt explores the streets and maze of alleyways of an area still rich in history and hidden delights and curiosities. The city is virtually deserted away from the tourist magnets of St Paul's Cathedral and The Monument.
Format
Participation is as individuals or teams of two. The Pedo lasts for three hours, and is made up of six consecutive thirty minute stages. A team starts at one of six checkpoints at a given starting time, is handed the first clue sheet, and makes its way to the next checkpoint during the allotted thirty minutes. Penalty points are accrued if a team is late arriving at a checkpoint.
Each clue sheet details a number of inscriptions to find (any written material is fair game, including graffiti, plaques, manhole covers, graves and so on). A point is scored for each answer obtained.
A 'Mini Pedo' version, which uses a smaller number of the clues on each clue sheet is recommended for newcomers.
The all-time record score is 71/72, obtained by Salem Al-Damluji and Anna Griffiths in 2014.
41st Avenue is a busy road in Vancouver, British Columbia. The road goes from the east side of Vancouver to the west side of Vancouver, where it merges on to Marine Drive.
Bus routes
has two bus routes that run on this road:
Bus 41 and Bus 43. Reserved lanes for express buses are being planned by TransLink and the city of Vancouver. Light rail transit may be built in the future.
SkyTrain
Oakridge-41st Avenue Station, a SkyTrain station on the Canada Line, is located at the intersection of 41st Avenue and Oakridge.
Police shooting
Vancouver police shot and killed a man with schizophrenia at the intersection of 41st Avenue and Knight Street on November 22, 2014.
Pollution from dry cleaning company
Land beneath a shopping centre at Cambie and 41st was reportedly contaminated with chemicals improperly disposed of by a dry cleaner.
Bus routes
has two bus routes that run on this road:
Bus 41 and Bus 43. Reserved lanes for express buses are being planned by TransLink and the city of Vancouver. Light rail transit may be built in the future.
SkyTrain
Oakridge-41st Avenue Station, a SkyTrain station on the Canada Line, is located at the intersection of 41st Avenue and Oakridge.
Police shooting
Vancouver police shot and killed a man with schizophrenia at the intersection of 41st Avenue and Knight Street on November 22, 2014.
Pollution from dry cleaning company
Land beneath a shopping centre at Cambie and 41st was reportedly contaminated with chemicals improperly disposed of by a dry cleaner.
The KiSel-10 Study was a randomized, placebo-controlled, double-blind clinical trial that was first reported in the International Journal of Cardiology in 2013. The full title of the report is “Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and Coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens.”
Purpose
Professor Urban Alehagen and a team of researchers at Linköping University designed and conducted the KiSel-10 study to investigate the effect of a daily combination of Coenzyme Q10 capsules and high-selenium yeast tablets on the extent of chronic heart failure, all-cause mortality, and cardiovascular mortality in senior citizens. The researchers' secondary objective was to determine whether the intervention with Coenzyme Q10 and selenium would influence cardiac function as evaluated by cardiac natriuretic peptides and by echocardiography.
Persistent Cardio-Protection
Professor Alehagen and the Linköping researchers used data from the records of the Swedish National Registry of Mortality to follow the senior citizens in the KiSel-10 study for 10 and 12 years following the beginning of the four-year intervention period. They were able to follow every participant, no one was lost to follow-up.
The follow-up studies showed that the senior Swedish citizens who had received combination of Coenzyme Q10 and high-selenium yeast continued to have a significantly lower cardiovascular mortality rate. The reduced cardiovascular mortality rate in the active treatment group held in patients with risk factors such as diabetes, hypertension, ischemic heart disease, and impaired functional capacity.
Possible Mechanisms of Action
Professor Alehagen and Professor Aaseth explained the beneficial effects of the combination supplementation by pointing to the antioxidant function of both Coenzyme Q10 in its reduced form and numerous selenium containing antioxidant seleno-enzymes.
There exists a special interrelationship between Coenzyme Q10 and selenium such that insufficient bio-availability of selenium can inhibit the cells from synthesizing adequate quantities of Coenzyme Q10 while, at the same time, the cells require adequate Coenzyme Q10 levels to realize optimal selenium function.
More specifically, Professor Alehagen documented specific effects of the combination supplementation that might explain the significantly reduced cardiovascular mortality in the senior citizens who received the Coenzyme Q10 and high-selenium yeast supplements:
Reduced levels of inflammation
Early on, the KiSel-10 researchers investigated the effect of the combination supplementation on the known bio-markers for inflammation: C-reactive protein and sP-selectin. The active treatment was associated with significantly decreased levels of C-reactive protein. The levels of the sP-selectin were elevated in both groups but were significantly elevated in the placebo group and only slightly elevated in the active treatment group.
In a later secondary analysis, the researchers found that the active treatment was associated with significantly reduced concentrations of the osteopontin, osteoprotegerin, sTNF receptor 1, and sTNF receptor 2 bio-markers for inflammation.
Reduced levels of oxidative stress
Professor Alehagen and the research team found that the combination supplementation of senior citizens had a beneficial effect on the levels of two known bio-markers for oxidative stress: copeptin and adrenomedullin.
Reduced levels of cardiac fibrosis
The Coenzyme Q10 and high-selenium yeast supplementation was associated with significantly reduced blood levels for seven out of the eight tested bio-markers for cardiac fibrosis.
Changed microRNA activity
Between the active treatment group and the placebo control group, there were significant differences in the expression of 70 microRNAs.
Increased insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein-1
Senior citizens in the Coenzyme Q10 and high-selenium yeast treatment group had significantly increased IGF-1 levels at the end of the study period. Senior citizens in the placebo group had reduced IGF-1 concentrations.
Purpose
Professor Urban Alehagen and a team of researchers at Linköping University designed and conducted the KiSel-10 study to investigate the effect of a daily combination of Coenzyme Q10 capsules and high-selenium yeast tablets on the extent of chronic heart failure, all-cause mortality, and cardiovascular mortality in senior citizens. The researchers' secondary objective was to determine whether the intervention with Coenzyme Q10 and selenium would influence cardiac function as evaluated by cardiac natriuretic peptides and by echocardiography.
Persistent Cardio-Protection
Professor Alehagen and the Linköping researchers used data from the records of the Swedish National Registry of Mortality to follow the senior citizens in the KiSel-10 study for 10 and 12 years following the beginning of the four-year intervention period. They were able to follow every participant, no one was lost to follow-up.
The follow-up studies showed that the senior Swedish citizens who had received combination of Coenzyme Q10 and high-selenium yeast continued to have a significantly lower cardiovascular mortality rate. The reduced cardiovascular mortality rate in the active treatment group held in patients with risk factors such as diabetes, hypertension, ischemic heart disease, and impaired functional capacity.
Possible Mechanisms of Action
Professor Alehagen and Professor Aaseth explained the beneficial effects of the combination supplementation by pointing to the antioxidant function of both Coenzyme Q10 in its reduced form and numerous selenium containing antioxidant seleno-enzymes.
There exists a special interrelationship between Coenzyme Q10 and selenium such that insufficient bio-availability of selenium can inhibit the cells from synthesizing adequate quantities of Coenzyme Q10 while, at the same time, the cells require adequate Coenzyme Q10 levels to realize optimal selenium function.
More specifically, Professor Alehagen documented specific effects of the combination supplementation that might explain the significantly reduced cardiovascular mortality in the senior citizens who received the Coenzyme Q10 and high-selenium yeast supplements:
Reduced levels of inflammation
Early on, the KiSel-10 researchers investigated the effect of the combination supplementation on the known bio-markers for inflammation: C-reactive protein and sP-selectin. The active treatment was associated with significantly decreased levels of C-reactive protein. The levels of the sP-selectin were elevated in both groups but were significantly elevated in the placebo group and only slightly elevated in the active treatment group.
In a later secondary analysis, the researchers found that the active treatment was associated with significantly reduced concentrations of the osteopontin, osteoprotegerin, sTNF receptor 1, and sTNF receptor 2 bio-markers for inflammation.
Reduced levels of oxidative stress
Professor Alehagen and the research team found that the combination supplementation of senior citizens had a beneficial effect on the levels of two known bio-markers for oxidative stress: copeptin and adrenomedullin.
Reduced levels of cardiac fibrosis
The Coenzyme Q10 and high-selenium yeast supplementation was associated with significantly reduced blood levels for seven out of the eight tested bio-markers for cardiac fibrosis.
Changed microRNA activity
Between the active treatment group and the placebo control group, there were significant differences in the expression of 70 microRNAs.
Increased insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein-1
Senior citizens in the Coenzyme Q10 and high-selenium yeast treatment group had significantly increased IGF-1 levels at the end of the study period. Senior citizens in the placebo group had reduced IGF-1 concentrations.
Carlo Ledesma (born 21 April 1975) is a Filipino film director, producer and screenwriter. Ledesma won the 2007 Best Short film at the Cannes Short Film Corner, for his film, The Haircut.
Ledesma directed The Tunnel, released on 18 May 2011. The film opened at the 2011 A Night of Horror International Film Festival in Sydney, garnering an award for Ledesma for Best Australian Director at the festival.
Ledesma co-written the film Saving Sally with director Avid Leongoren and Charlene Sawit-Esguerra, it was released on December 25, 2016 at the 2016 Metro Manila Film Festival.
In 2001, Ledesma became a segment producer for GAMEPLAN earlier in his career.
Ledesma directed The Tunnel, released on 18 May 2011. The film opened at the 2011 A Night of Horror International Film Festival in Sydney, garnering an award for Ledesma for Best Australian Director at the festival.
Ledesma co-written the film Saving Sally with director Avid Leongoren and Charlene Sawit-Esguerra, it was released on December 25, 2016 at the 2016 Metro Manila Film Festival.
In 2001, Ledesma became a segment producer for GAMEPLAN earlier in his career.