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Phosphoinositide phospholipase C
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In enzymology, a phosphoinositide phospholipase C () is an enzyme that catalyzes the chemical reaction :1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol Thus, the two substrates of this enzyme are 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate and H2O, whereas its two products are 1D-myo-inositol 1,4,5-trisphosphate and diacylglycerol. This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase. Other names in common use include triphosphoinositide phosphodiesterase, phosphoinositidase C, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase, monophosphatidylinositol phosphodiesterase, phosphatidylinositol phospholipase C, PI-PLC, 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate, and inositoltrisphosphohydrolase. This enzyme participates in 18 metabolic pathways: inositol phosphate metabolism, erbb signaling pathway, calcium signaling pathway, phosphatidylinositol signaling system, wnt signaling pathway, vegf signaling pathway, gap junction, natural killer cell mediated cytotoxicity, fc epsilon ri signaling pathway, leukocyte transendothelial migration, long-term potentiation, long-term depression, gnrh signaling pathway, melanogenesis, epithelial cell signaling in helicobacter pylori, , glioma, and non-small cell lung cancer. Structural studies As of late 2007, 23 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , , , , , , , , , , , , , , , , , and . 
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