Meiosis XY Female Syndrome

Meiosis XY Female Syndrome is a rare sex chromosomal condition. It is caused by unequal crossing over between y and x chromosomes during meiosis, which results in the y chromosomes containing the normally female sex determining gene. This results in a person who is genetically male but anatomically a full female. Meiosis XY Female Syndrome women have vaginas, cervixes, uteruses and fallopian tubes. They lack the female gene that causes ova production however and are always sterile. They menstruate just like biologically female women. They are often taller than average women. They do not require estrogens or other female hormones to maintain their normal female appearances. Such women have been studied by the noted pediatric endocrinologist Charmian Quigley. The sexual orientation of Meiosis XY Female Syndrome women has not been fully studied. This syndrome is different than Androgen Insensitivity Syndrome as it does not involve an insensitivity to androgen hormones. Another rare condition creating a phenotypical female whose chromosomal pattern is male is when part of the SRY gene is damaged, missing or destroyed. A female embryo is produced with full female phenotype but with rudimentary ovaries.

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