Kambiz Alavian

Kambiz N. Alavian, Ph.D. is an Iranian-American neuroscientist and a lecturer in the Division of Brain Sciences, Department of Medicine at Imperial College London. He is also an Assistant Professor (Adjunct) of Medicine at Yale University School of Medicine.
Early life and education
Alavian received his B.S. and M.S. degrees in biological sciences from University of Illinois at Chicago and Illinois Institute of Technology, respectively. He received his Ph.D. in Neuroscience from University of Heidelberg in Germany and completed postdoctoral training at Harvard Medical School and Yale University School of Medicine.
Career
In 2011, in an article published by Nature Cell Biology, Dr. Alavian and his co-authors found that Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase.
Alavian's research in recent years has been focused on the molecular characterization of mitochondrial bioenergetics, calcium homeostasis, and cell death.
Awards
In 2012, he received Young Bioenergeticist Award given by the Biophysical Society.
Selected publications
* Alavian, K.N., Scholz, C. and Simon, H.H., Transcriptional regulation of mesencephalic dopaminergic neurons: the full circle of life and death. Mov Disord, 2008. 23(3): p. 319-328. (review)
* Sgado, P., Alberi, L., Gherbassi, D., Galasso, S.L., Ramakers, G.M., Alavian, K.N., Smidt, M.P., Dyck, R.H. and Simon, H.H., Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice. Proc Natl Acad Sci USA, 2006. 103(41): p. 15242-15247.
* Alavian, K.N., Sgado, P., Alberi, L., Subramaniam, S., and Simon, H.H., Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression. Neural Dev, 2009. 4: p. 11.
* Alavian, K.N., Li, H., Collis, L., Bonanni, L., Zeng, L., Sacchetti, S., Lazrove, E., Nabili, P., Flaherty, B., Graham, M., Chen, Y., Messerli, S.M., Mariggio, M.A., Rahner, C., McNay, E., Shore, G.C., Smith, P.J., Hardwick, J.M. and Jonas, E.A., Bcl-x(L) regulates metabolic efficiency of neurons through interaction with the mitochondrial F(1)F(O) ATP synthase. Nature Cell Biol, 2011. 13(10): p. 1224-1233.
* Chen, Y.B., Aon, M.A., Hsu, Y.T., Soane, L., Teng, X., McCaffery, J.M., Cheng, W.C., Qi, B., Li, H., Alavian, K.N., Dayhoff-Brannigan, M., Zou, S., Pineda, F.J., O'Rourke, B., Ko, Y.H., Pedersen, P.L., Kaczmarek, L.K., Jonas, E.A. and Hardwick, J.M., Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential. Journal of Cell Biology, 2011. 195(2), 263-276.
* Ofengeim, D., Chen, Y.-B., Miyawaki T, Li, H., Sacchetti, S., Flannery, R., Alavian, K.N., Pontarelli, F., Hickman, J.A., Hardwick, J.M., Zukin, R.S. and Jonas, E.A., N-terminally cleaved Bcl-xL mediates ischemia-induced neuronal death. Nature Neuroscience, 2012. 10.1038/nn.3054.
* Alavian, K.N., Dworetzky, S.I., Bonanni, L., Zhang, P., Sacchetti, S., Li, H., Mangold, J., Signore, A., DeMarco, U., Damady, D., Smith, P.J.S., Gribkoff, V.K. and Jonas, E.A., Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency. Brain Research, 2012. 10.1016/j.brainres.2012.01.046.
* Li, H., Alavian, K. N., Lazrove, E., Mehta, N., Jones, A., Zhang, P., . . . Jonas, E. A. (2013). A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. Nat Cell Biol, 15(7), 773-785. doi: 10.1038/ncb2791
* Alavian, KN., Beutner, G., Lazrove, E., Sacchetti, S., Park, H., Licznerski, P., Li, H., Nabili, P., Hockensmith, K., Graham, M., Porter, Jr., G.A. and Elizabeth A. Jonas (2014) An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore. PNAS (2014) doi : 1401591111v1-201401591.

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