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Grant Goodwin
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Grant Goodwin is the name of a Scotsman who died at the age of 30 in December 2008 from vCJD. Professor Peter Rudge identified him as the first person in the world with heterozygous Methionine-Valine gene at amino acid 129 (aka "the prion gene") to die of the disease. Every other person who died from vCJD has had a homozygous Methionine-Methionine form of prion gene. Of the overall Caucasian population, about 40% have two methionine-containing alleles, 10% have two valine-containing alleles, and the other 50% are heterozygous at this position. Symptoms The personality of Goodwin "changed and he became depressed". In 2008, his parents took him home to Scotland from the Channel Islands, where he had been working as an engineer, when he complained of "pain in his legs and head". His father Tommy remarked that<ref nameson/><ref namegene/> |
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