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Diversolide
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The Diversolides are a group of chemical compounds in the family of sesquiterpene lactones isolated from the roots of Ferula diversivittata. History In 2008, Mehrdad Iranshahi from Mashhad University of Medical Sciences in Mashhad, Iran and his research group found seven sesquiterpene lactone derivatives which were isolated from the roots of Ferula diversivittata. They named them diversolides A-G (1-7). The group members were Mehrdad Iranshahi and Seyyed Tahmineh Hosseini(Mashhad University of Medical Sciences,Mashhad,Iran), Ahmad Reza Shahverdi and Kamyar Mollazadeh Moghaddam (from Tehran University of Medical Sciences, Tehran, Iran) and Saleha Suleman Khan and Viqar Uddin Ahmad (from International Center for Chemical and Biological Sciences, Karachi, Pakistan). Biological activities Compounds 1, 4, and 6-8 were tested for their in vitro antifungal and antibacterial activities against Staphylococcus aureus, Escherichia coli, Aspergillus niger and Candida albicans using gentamycin and fluconazole as positive controls. The compounds did not show any antifungal activity against Candida albicans at a range of 1.25-160 micrograms per mililiter. A lack of activity at a level of 160 μg/mL was considered "inactive". However, Staphylococcus aureus, Escherichia coli, Aspergillus niger had different susceptibility to the compounds at concentrations lower than 160 μg/mL. The best antimicrobial activity was observed against the filamentous fungus Aspergillus niger. This fungus was susceptible to all tested compounds, except to compound 1. Chemical structure Diversolide A (1); 2-methyl-but-2-enoic 3,6,9-trimethyl-3-(2-methyl-but-2-enoyloxy)-2,7-dioxo-2,3,3a,4,5,7,9a,9b-octahydro-azulenofuran-4-yl ester Diversolide B (2); 2-methyl-but-2-enoic 3,6,9-trimethyl-3-(3-methyl-but-2-enoyloxy)-2,7-dioxo-2,3,3a,4,5,7,9a,9b-octahydro-azulenofuran-4-yl ester Diversolide C (3) ; benzoic acid 3,6,9-trimethyl-3-(3-methyl-but-2-enoyloxy)-2,7-dioxo-2,3,3a,4,5,7,9a,9b-octahydro-azulenofuran-4-yl ester Diversolide D (4); benzoic acid 3-acetoxy-3,6,9-trimethyl-2,7-dioxo-2,3,3a,4,5,7,9a,9b-octahydro-azulenofuran-4-yl ester Diversolide E (5); 3,4-dimethoxy-benzoic acid 3,6,9-trimethyl-3-(2-methyl-but-2-enoyloxy)-2,7-dioxo-2,3,3a,4,5,7,9a,9b-octahydro-azulenofuran-4-yl ester Diversolide F (6); 3,4-dimethoxy-benzoic acid 3,6,9-trimethyl-3-(3-methyl-but-2-enoyloxy)-2,7-dioxo-2,3,3a,4,5,7,9a,9b-octahydro-azulenofuran-4-yl ester Diversolide G (7); 3,4-dimethoxy-benzoic acid 3-acetoxy-3,6,9-trimethyl-2,7-dioxo-2,3,3a,4,5,7,9a,9b-octahydro-azulenofuran-4-yl ester See Also
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