Aging Research Centre

The The Aging Research Centre (ARC) is an independent non-profit educational research centre founded by Steven A. Garan, with facilities in Berkeley, California and in Waterloo, Ontario. Founded in 1994, it focuses its research in three areas: (1) the assembling and linking together of existing knowledge with respect to the aging process in animals, (2) engaging in experiments that shed light on the neuroendocrinology of aging, and the (3) creation of new tools that allow researchers to study the aging process.
Throughout the years, researchers at the Aging Research Centre have presented their research results at many academic conferences and published numerous articles ranging from the effects of caloric restriction on the cell density in the pre-optic hypothalamus, to the systems biology of aging, to articles on an Automated Imaging Microscope System (AIMS) that was developed by ARC researchers in collaboration with researchers at the University of California, Berkeley.
Publications
* [http://www.sciencedirect.com/science?_obArticleURL&_udiB6T6J-4V4KGYS-J&_user10&_coverDate02%2F28%2F2009&_rdoc34&_fmthigh&_origbrowse&_srchdoc-info(%23toc%235032%232009%23999559998%23764056%23FLA%23display%23Volume)&_cdi5032&_sortd&_docanchor&_ct51&_acctC000050221&_version1&_urlVersion0&_userid10&md5=f508c954d19e3349df9d2f556d5e7271 Shortest path algorithms combined with natural language parsing, map pathways involved in neuroendocrine aging. Experimental Gerontology, Volume 44, Issues 1-2, January-February 2009, Page 129].
* [http://www.sciencedirect.com/science?_obArticleURL&_udiB6T6J-4KGG1P4-C&_user10&_handleC-WA-A-VD-VD-MsSAYWB-UUW-U-U-VD-U-U-AADUEEDBAV-AAZYCDYAAV-WUBCCYBZA-VD-U&_fmtfull&_coverDate02%2F28%2F2007&_rdoc29&_origbrowse&_srch=%23toc%235032%232007%23999579998%23639966!&_cdi5032&_acctC000050221&_version1&_urlVersion0&_userid10&md5e1fda3bc4b0ccb336fb38988703637d6 A computational systems biology approach to neuroendocrine aging: Initial results. Experimental Gerontology, Volume 42, Issues 1-2 , January-February 2007, Page 142]
* [http://www.sciencedirect.com/science?_obArticleURL&_udiB6T6J-4KGG1P4-B&_user10&_handleC-WA-A-VD-VD-MsSAYWB-UUW-U-U-VD-U-U-AADUEEDBAV-AAZYCDYAAV-WUBCCYBZA-VD-U&_fmtfull&_coverDate02%2F28%2F2007&_rdoc28&_origbrowse&_srch=%23toc%235032%232007%23999579998%23639966!&_cdi5032&_acctC000050221&_version1&_urlVersion0&_userid10&md52e1993c5025659810f6ce66fd3135f4f Novel methods in computer-assisted tissue analysis: Customized regional targeting of both cytoplasmic and nuclear-stained tissue. Experimental Gerontology, Volume 42, Issues 1-2 , January-February 2007, Pages 141-142]
* [http://www.sciencedirect.com/science?_obArticleURL&_udiB6T6J-4KGG1P4-10&_user10&_handleC-WA-A-VD-VD-MsSAYWB-UUW-U-U-VD-U-U-AADUEEDBAV-AAZYCDYAAV-WUBCCYBZA-VD-U&_fmtfull&_coverDate02%2F28%2F2007&_rdoc45&_origbrowse&_srch=%23toc%235032%232007%23999579998%23639966!&_cdi5032&_acctC000050221&_version1&_urlVersion0&_userid10&md5d5741475a812c1d5a283114bba5379a8 Tracking changes in hypothalamic IGF-1 sensitivity with aging and caloric restriction. Experimental Gerontology, Volume 42, Issues 1-2 , January-February 2007, Pages 11-12.]
* [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?dbpubmed&cmdRetrieve&doptAbstractPlus&list_uids17194562&query_hl3&itoolpubmed_docsum Insulin-like growth factor-1 receptor immunoreactive cells are selectively maintained in the paraventricular hypothalamus of calorically restricted mice. Int J Dev Neurosci. 2007 Feb;25(1):23-8]
* [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?dbpubmed&cmdRetrieve&doptAbstractPlus&list_uids17034982&query_hl3&itoolpubmed_docsum Age-dependent loss of insulin-like growth factor-1 receptor immunoreactive cells in the supraoptic hypothalamus is reduced in calorically restricted mice. Int J Dev Neurosci. 2006 Nov;24(7):431-6.]
* [http://www.fasebj.org/cgi/content/meeting_abstract/20/4/A536?maxtoshow&HITS10&hits10&RESULTFORMAT&FIRSTINDEX0&volume20&issue4&resourcetypeHWCIT A study of insulin-like growth factor-I receptor immunoreactivity in the supraoptic nucleus of young and old female B6D2F1 mice. FASEB Journal, April 2006, 357.5]
* [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?dbpubmed&cmdRetrieve&doptAbstractPlus&list_uids15990721&query_hl3&itoolpubmed_docsum Caloric restriction reduces cell loss and maintains estrogen receptor-alpha immunoreactivity in the pre-optic hypothalamus of female B6D2F1 mice, Neuro Endocrinol Lett. 2005 Jun;26(3):197-203. ]
* [http://www.sciencedirect.com/science?_obMImg&_imagekeyB6T6J-4DK6DF0-1-1&_cdi5032&_user10&_origbrowse&_coverDate11%2F01%2F2004&_sk999609988&viewc&wchpdGLzVlz-zSkWW&md53b4c858a77ad92f1e24cbcf3c26e895e&ie=/sdarticle.pdf A survey of estrogen receptor-alpha immunoreactivity in the hypothalamus of young, old, and old-calorie restricted female B6D2F1 mice, Experimental Gerontology, Volume 39, Issues 11-12, November-December 2004, Page 1771]
* [http://www.sciencedirect.com/science?_obMImg&_imagekeyB6T6J-4DK6DF0-1-1&_cdi5032&_user10&_origbrowse&_coverDate11%2F01%2F2004&_sk999609988&viewc&wchpdGLzVlz-zSkWW&md53b4c858a77ad92f1e24cbcf3c26e895e&ie=/sdarticle.pdf Protocol for higher resolution histological images of the mammalian brain, Experimental Gerontology, Volume 39, Issues 11-12, November-December 2004, Page 1770]
* [http://www.sciencedirect.com/science?_obMImg&_imagekeyB6T6J-4DK6DF0-1-1&_cdi5032&_user10&_origbrowse&_coverDate11%2F01%2F2004&_sk999609988&viewc&wchpdGLzVlz-zSkWW&md53b4c858a77ad92f1e24cbcf3c26e895e&ie=/sdarticle.pdf Towards a self-learning, self-assembling systemic map of neuroendocrine aging, Experimental Gerontology, Volume 39, Issues 11-12, November-December 2004, Page 1767]
* [http://www.sciencedirect.com/science?_obMImg&_imagekeyB6T6J-47PFF8R-2-1&_cdi5032&_user10&_origbrowse&_coverDate01%2F31%2F2003&_sk999619998&viewc&wchpdGLbVzz-zSkzS&md58fdf809ce9f016009996765239c71491&ie=/sdarticle.pdf Phenomics: a new direction for the study of neuroendocrine aging. Experimental Gerontology, Volume 38 (2003), Issues 1-2, Page 218]
* [http://www.sciencedirect.com/science?_obMImg&_imagekeyB6T6J-47PFF8R-2-1&_cdi5032&_user10&_origbrowse&_coverDate01%2F31%2F2003&_sk999619998&viewc&wchpdGLbVzz-zSkzS&md58fdf809ce9f016009996765239c71491&ie=/sdarticle.pdf A comparison of estrogen receptor-alpha immunoreactivity in the arcuate hypothalamus of young and middle-aged C57BL6 female mice. Experimental Gerontology, Volume 38 (2003), Issues 1-2, Page 220]

* [http://www.sciencedirect.com/science?_obPublicationURL&_cdi5032&_pubTypeJ&_authy&_acctC000050221&_version1&_urlVersion0&_userid10&md5068c874a21c5a227d3977047c875f30c&jchunk35#35 Creating Three-Dimensional Neuronal Maps of the Mouse Hypothalamus Using an Automated Imaging Microscope System. Experimental Gerontology, Volume 35 numbers 9-10, December 2000, page 1421]
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