Sir William de la Pole (died 1329) was the eldest son of Owen de la Pole, grandson of Gruffydd ap Gwenwynwyn and was the heir presumptive of the throne of Powys Wenwynwyn.
Sir William de la Pole was born in exile in 1275 in Kingston upon Hull and had several younger brothers including Lewis de la Pole, Owen de la Pole and Griffin de la Pole, any of which could claim to be the de jure Prince of Powys Wenwynwyn. His family was restored to their lands after the defeat of the princes of the Kingdom of Gwynedd in 1277 but lost their princely titles following the Statute of Rhuddlan.
Sir William married Elena Rotenheryng and died sometime before 1329. He had two children.