Recaldent

Recaldent, with the technical name casein phosphopeptide - amorphous calcium phosphate, or CPP-ACP, is a milk-derived product that is claimed to remineralize teeth and help prevent dental caries, also known as tooth decay.
The scientific research which led to the development of Recaldent™ began in the 1980s. Over 20 years, researchers at the Melbourne Dental School (University of Melbourne), led by Professor Eric Reynolds, investigated the casein protein in milk until they were able to identify and isolate the CPP-ACP complex.
Properties
Casein phosphopeptides (CPP) from the major protein of milk have the ability to stabilize calcium, phosphate and fluoride ions as water-soluble amorphous complexes that provide bioavailable calcium, phosphate and fluoride ions to the tooth. These complexes of amorphous calcium phosphate and amorphous calcium fluoride phosphate stabilized by the CPP have been demonstrated in a range of laboratory, animal and short-term human clinical trials to repair (remineralise) early stages of tooth decay by replacing the calcium and phosphate ions lost due to decay. Three longer-term, randomized, controlled clinical trials have demonstrated the efficacy of CPP-ACP in slowing the progression of dental caries and in regressing (repairing) early stages of tooth decay. Another randomly controlled trial showed that CPP and calcium carbonate in a toothpaste formulation, which would spontaneously form CPP-ACP in saliva, significantly reduced caries experience in children compared with a control toothpaste. A systematic review with meta-analysis by Yengopal and Mickenautsch concluded that “the results of the clinical in situ trials indicate a short-term remineralization effect of CPP-ACP. Additionally, the promising in vivo RCT results suggest a caries-preventing effect for long-term clinical CPP-ACP use”. Recaldent (CPP-ACP) can be applied to the teeth via sugar-free gum, medicated tooth crème and fortified dairy milk.

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