Open PHACTS

Open PHACTS,, (the Open Pharmacological Concepts Triple Store) is a project to deliver a single view across available data resources of value to drug discovery and the pharmaceutical industry. It is a European research project funded under the Innovative Medicines Initiative. It deploys a highly innovative open standards, open access, semantic web approach to address key bottlenecks in small molecule drug discovery - disparate information sources, lack of standards and information overload. It is an open, integrated and sustainable chemistry, biology and pharmacology knowledge resource for project partners in the drug discovery industry and will be released to the community within the three year lifetime of the project. The project provides tools for a comprehensive platform of chemical, biological and pharmacological information, confederated from vast, distributed and variable data and information sources. This semantically enriched and fully interoperable platform resulting from the three year project, initiated in March 2011, will deliver information on small molecules and their pharmacological profiles, including pharmacokinetics and ADMET data as well as on biological targets and pathways. A proof of concept view of the Open PHACTS platform is already available online.
The platform proposed by the partners listed below will be a widely accessible, open innovation platform that will serve EFPIA partners as well as biotech and academic drug-discovery researchers for one of their core business activities: knowledge discovery and verification. Practicing drug-discovery scientists in both the public and the private sector will turn to this service to:
- integrate data on target expression, biological pathways and pharmacology to identify the most productive points for therapeutic intervention
- investigate the in vitro pharmacology and mode-of-action of novel targets to help develop screening assays for drug discovery programs
- compare molecular interaction profiles to assess potential off-target effects and safety pharmacology
- analyse chemical motifs against biological effects to deconvolute high content biology assays
Partners
The Open PHACTS consortium comprises 23 European core partners, with leading experts in the fields of data mining, annotation, small molecule data storage and manipulation, target related bioinformatics, pathway annotation, protein structure analysis, massive daily in silico reasoning, chemical biology, and computational chemistry. These are: Pfizer, Universität Wien, Technical University of Denmark, University of Hamburg, BioSolveIT GmBH, Consorci Mar Parc de Salut de Barcelona, Leiden University Medical Centre, Netherlands Bioinformatics Centre, Royal Society of Chemistry, Vrije Universiteit, Spanish National Cancer Research Centre, University of Manchester, Maastricht University, Academic Concept Knowledge Ltd, University of Santiago de Compostela, Rheinische Friedrich-Wilhelms-Universität Bonn, AstraZeneca, GlaxoSmithKline, Laboratorios del Dr. Esteve, Novartis, Merck KGaA, Lundbeck, and Eli Lilly.
People
Participants include Gerhard Ecker, Carole Goble (Taverna workbench, myGrid, BioCatalogue and myExperiment), Barend Mons (Open Source Wiki-technology), Antony Williams (ChemSpider), Frank van Harmelen (LarKc), Chris Evelo (WikiPathways//Pathvisio), Paul Groth (LarKc), Jan Velterop.

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