Nimesh Gupta

Dr. Nimesh Gupta, an Indian vaccine immunologist, is a senior scientist and the Head of the Vaccine Immunology Laboratory at the National Institute of Immunology in India. His research focuses on understanding T-cell immunity to virus infections and vaccinations . Dr. Gupta also established the Human Immune Monitoring and T-cell Assay Platform for advanced testing of vaccines .
Education and academic posts
Nimesh earned his Bachelor of Science in Microbiology and Master of Science in Biotechnology from Jiwaji University, Gwalior. He then completed his Ph.D. in 2011 from Jiwaji University and the Defence Research and Development Organisation (DRDO) in Gwalior.
In 2008, as a Raman Charpak Fellow, Nimesh conducted his doctoral research at the Institut Pasteur in Paris, France. Following this, he pursued postdoctoral research at the Centre de recherche des Cordeliers in Paris, France, where he focused on T-cell immunology and viral immunity. In 2015, he joined the National Institute of Immunology in India as a Scientist and established the Vaccine Immunology Laboratory.
Research
Nimesh's research has primarily focused on investigating T-cell immunity in the context of viral infections and vaccines. His research programs utilize longitudinal cohorts of controlled vaccination and human viral infections, such as Dengue, Japanese encephalitis, and COVID-19. In collaboration with AIIMS, Nimesh published a report on the immune response to SARS-CoV-2 in the Indian population. The study revealed that, prior to the pandemic, the Indian population already possessed cross-reactive T cells to SARS-CoV-2 and demonstrated that the immune memory response (T cells and B cells) to the virus exhibited durability traits. This study provided crucial insights into the type of immunity generated in the Indian population following exposure to SARS-CoV-2.
In a multi-centric collaboration, Nimesh published a report on the characteristics of the immune memory response to inactivated virus vaccine. This study provided evidence on the quality and durability of immune memory established by the inactivated COVID-19 vaccine and its response to SARS-CoV-2 variants . Nimesh's team also contributed essential knowledge on the mechanism of protective immunity induced by the historical live attenuated Japanese encephalitis (JE) vaccine (SA14142) .

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