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Landmark Clinical Trials
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In the last two decades, there have been a number of large, randomized clinical trials that have shaped the way medicine is practiced. This page lists some of the major trials in several areas. Heart Failure RALES: In patients with NYHA III and IV heart failure, spironolactone added to a beta-blocker and an ACE-inhibitor decreased all-cause mortality. AF-CHF: In patients with both atrial fibrillation and congestive heart failure, rate control was as effective as rhythm control in decreasing all-cause mortality. Diabetes ADOPT DREAM UKPDS ACCORD Hypertension HYVAT DASH VADT PROGRESS Surgery POISE Hyperlipidaemia CARDS Framingham DASH Anticoagulation AFFIRM CLARITY CURE (NEJM, 2001): In patients with NSTEMI or unstable angina, clopidogrel + ASA was superior to ASA alone in preventing MI, stroke, and CVD-related death, although the risk of major bleeding was increased. Stroke NINDS ECASS PRoFESS (NEJM, 2008): ASA + dipyridamole is as effective as clopidogrel in the prevention of stroke. The risk of intracranial haemorrhage was higher in the clopidogrel group. See Also
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