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HIF strengthening factor
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A HIF strengthening factor (HSF) is a molecule to stimulate the signaling pathway. The 2019 Nobel Prize in Physiology or Medicine was awarded for the discovery of HIF. HIFs are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia. The hypoxia in wounds promotes the migration of keratinocytes and the restoration of the epithelium. It is therefore not surprising that HIF-1 modulation was identified as a promising treatment paradigm in wound healing. This insight led to the development of HIF Strengthening Factors (HSF) to induce repair, regeneration and rejuvenation. Researchers at the Stanford University School of Medicine demonstrated that HIF-1 activation was able to prevent and treat chronic wounds in diabetic and aged mice. Not only did the wounds in the mice heal more quickly, but the quality of the new skin was even better than the original. Additionally the regenerative effect of HIF-1 modulation on aged skin cells was described and a rejuvenating effect on aged facial skin via HSF treatment was demonstrated in patients. HIF activation has also been linked to a beneficial effect on hair loss. See Also
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