The Computational Chemistry Grid project (CCG) is a National Science Foundation project in computational chemistry. The CCG is a virtual organization that allocates time on high-performance computing (HPC) resources for running computational chemistry applications through distributed support and services using an intuitive client called GridChem. GridChem is a Java Desktop software application that presents a common interface to the user, integrating authentication, molecular editing, input and job preparation, job submission, and output monitoring. The GridChem Middleware Services manages and monitors execution of applications on the HPC resources through web services, and hosts consulting and allocations services. The computational power includes several Intel processor clusters, IBM Power4 and SGI Origin 2000. Computing-sensitive areas include: *quantum chemistry Participants *National Science Foundation *National Center for Supercomputing Applications *Center for Computation and Technology at Louisiana State University *Texas Advanced Computing Center *Ohio Supercomputer Center *Center for Computational Sciences, University of Kentucky