Artificial microRNA

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Artificial microRNA (amiRNA) ia a type of miRNA which is derived by replacing native miRNA duplexes from a natural miRNA precursor.
Key features of an amiRNA
* An amiRNA should have secondary structural similarity that of its precursor.
* It can be processed by host machinery as normal miRNA.
* After processing it will produce amiRNA:amiRNA* duplex instead of natural miRNA:miRNA* duplex.
* It should have the ability to confer PTGS to a specific target.
Types of amiRNA
* monocistronic amiRNA- amiRNA produces only one amiRNA:amiRNA* duplex
* Dicistronic amiRNA- produces two amiRNA:amiRNA duplex of same type or different type
* Polycistronic amiRNA- can produce more than two types of amiRNA:amiRNA* duplex
Use of amiRNA
*amiRNA is a new strategy having huge potential. As a PTGS, it is tested to confer viral resistance in plants. Nonetheless, more research must be done to improve a better strategy which can confer resistance to fungal and bacterial diseases.

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