Anatoly I. Gozhenko

Anatoly I. Gozhenko (1948) is MD, Professor, Honored Worker of Science of Ukraine ( 1998), Director of "Ukrainian Research Institute of Transport Medicine” (Odessa).
He graduated from Chernovtsy Medical Institute, and entered a PhD programme, in 1976 he was awarded his candidate degree on medicine. From 1981 to 1989 he worked at the position of the head of the department of pathological physiology in the named institute. In 1989 he moved to Odessa and became first head of the laboratory of food hygiene at the All-Union Research Institute of Water Transport Hygiene ( nowadays - Ukrainian Research Institute of Transport Medicine), then research director of Ukrainian scientific-practical union "Medicine of Transport" (1992-1999), head of the department of general and clinical pathological physiology of Odessa state medical university (1999-2012).
In 1998 by Presidential Decree prof. Gozhenko was awarded the honorary title "Honored Worker of Science of Ukraine» for the achievements in health care development, introduction of new methods of diagnosis and treatment, and high professional competence.
Prof. Gozhenko is one of the leading Ukrainian scientists in the field of clinical pathological physiology and the founder of Ukrainian school of clinical pathophysiologists. He developed innovative general theory of disease that justifies the current paradigm of illness as pathology self-development and a body’s adaptation at damage, so the disease is the only possible form of a damaged body adaptation to the environment, that is evolutionarily formed and genetically fixed.
Prof. Gozhenko’s multifaceted scientific activity has an expressed fundamental character and aims to clarify the mechanisms of disease and the development of evidence-based medicine on the principles of effective methods of diagnosis, treatment and rehabilitation.
During his work he clarified mechanisms of acute renal failure, the role of prostaglandins, renin-angiotensin system and nitric oxide in their development. Prof. Gozhenko first deciphered the mechanism of reduction of glomerular filtration during the acute kidney injury and has proven its adaptive character; established primary character of proximal tubular damage in the genesis of reduced glomerular filtration and formation of acute renal failure. It was AI Gozhenko who one of the first has studied the mechanisms of non-immunologic progression of kidney diseases. He proposed a new method for determination of renal functional reserve and proved its diagnostic value in clinical practice and experimental studies. Prof. Gozhenko had learnt the role of nitric oxide in the physiology and pathology of hemostasis, inflammatory and neoplastic processes, its relationship with NO-synthase systems in myocardium, the presence of NO-dependent mechanisms in stimulation of reproductive system and so on.
He formulated pathogenetic bases of liver diseases and contribution of H. pylori infection in the etiology of stomach diseases.
Under the leadership of prof. Gozhenko a novel cycle of works on thermometry, which describes theoretical mechanisms and shows practical measurement value of a body’s heat flow has been fulfilled.
Influenza’s antiproteinase treatment was pathogenetically substantiated as well.
This is by far not a complete list of new experimentally and clinically proven theoretical positions offered by Prof. Gozhenko. Among them the following should be mentioned:
- in the field of physiology - the theory of preventive regulation of water-salt metabolism;
- in the field of pathophysiology - the role of clinical pathophysiology in determination of the etiology of occupational diseases has been proven and formulated the new paradigm of disease;
- in the field of renal pathophysiology - first formulated the laws of development of pathological processes in the kidney;
- in the field of toxicology - established the primary mechanism of the toxic effect of heavy metals on kidney damage;
- in the field of epidemiology - took part in the justification of protease-inhibition theory of influenza pathogenesis.
Theoretical developments of AI Gozhenko are reflected in 18 guidelines and 71 patents on methods of diagnosis, treatment and rehabilitation in various pathological conditions. He is co-author of 2 devices approved for industrial production in Ukraine; co-author of ISO 7525: 2014 "Drinking water. Requirements and quality control methods, the order of Ukrainian Ministry of Health Care on medical and physiological examinations of workers of transport and so on.
Professor AI Gozhenko authored more than 1.400 academic papers, including 46 monographs, 71 patents, 5 books, 3 textbooks, curriculum for higher medical (pharmaceutical) educational institutions.
He created an international scientific school "Pathophysiology of water-salt metabolism and kidney function," which includes 66 qualified specialists and scientists in Ukraine, Russia, Poland, Canada and India. Under his supervision and counseling 24 doctors and 51 candidates of medicine have been trained. He is the chief editor of several journals, e.g. "Actual Problems of Transport Medicine", "Journal of Maritime Medicine", "Water: hygiene and ecology», «Journal of Education, Health and Sport» (Poland); member of the editorial boards of 7 domestic and 2 international scientific journals.
His is honorable professor-emeritus of several Ukrainian and foreign higher education institutions, a member of the Board of Ukrainian society for pathophysiologists, International association of maritime health (IMHA). He
delivered lectures on maritime medicine in medical university “Prof. Dr. Paraskev Stoyanov” (Bulgaria), took part in consultations of European bureau of WHO (Denmark)

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