14-cinnamyl 3-acetyl oxymorphone

14-cinnamyl 3-acetyl oxymorphone is a narcotic analgesic which is structurally related both to oxymorphone and heroin. It is 20 times stronger than oxymorphone and therefore 200 times stronger than morphine. The hydrochloride salt appears to be the one used in research. The cinnamyl group at position 14 on the morphine carbon skeleton is most of the reason that this drug is so much stronger than oxymorphone and the acetylated derivatives thereof; this group is also present in other ultra-potent semi-synthetic opioids. It is also one of three changes to the morphine molecule to obtain the drug: secondly it is a morphinone type opioid and thirdly it is acetylated at the 3 position. The last two make it possible for the drug to cross the blood-brain barrier more rapidly and in greater quantity per unit of time and therefore have a stronger action with a more rapid onset.
Effective analgesic doses of this agent are in the microgramme range and it is intermediate in potency between the main set of semi-synthetics and the Bentley compounds, the latter of which include etorphine (Immobilon). Given that dihydroetorphine is used in medicine in some countries, it would seem to be possible to use 14-cinnamyl 3-acetyl oxymorphone as a strong centrally-acting analgesic just as oxymorphone is used. It can be extrapolated that the duration of action of this drug is in the 4 to 7 hour range.
As it stands now, 14-cinnamyl 3-acetyl oxymorphone is not available as a medication and is subject to regulation under the laws of many countries as well as the 1930 League of Nations action to ban heroin analogues; if this drug is not specified in the drugs law of a given country, it is usually banned by laws and treaties dealing with designer drugs since it contains the morphine carbon skeleton and has similar effects.
This drug is not widely used in medicine. Clandestine manufacture of the drug would be somewhat more complicated and difficult compared to the preparation of heroin, thebacon, acetyldihydrocodeine, acetylmorphone, or diacetyloxymorphone by means of acetylation with acetic anhydride, the first of these being called Homebake.

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